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The side effects of prostate cancer treatment, including impotence and incontinence, are hardly trivial, but many men have been willing to risk them in the hope that they'd avoid an even scarier consequence € death. Last week, Consumers Union, the publisher of Consumer

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Reports, released a list of "Best Buy Drugs" based on data on the relative effectiveness, cost, and
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side effects of drugs in more than two dozen drug classes. (My colleague Tybi Healy offers some analysis of the PSA screening studies.) At this time, however, comparative effectiveness research
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enters very little into most of our healthcare experiences. If that doesn't work, the dose is doubled. And while I understand the concern that data could eventually be used to deny care if treatment is deemed not effective enough or too pricey, that hardly justifies not doing the research in the first place. Two long-term studies have
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been evaluating whether the PSA test € the
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blood test that screens for prostate cancer € actually saves lives. Research Ahmed has conducted on various cholesterol-lowering drugs, for example, has led Arne to recommend that its clinicians prescribe generic simvastatin as a first-line treatment for patients with heart disease or diabetes.

It's hard to understand how reasonable

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data so that we can actually know if one drug or medical device works better than another at fixing the same medical problem. Until now, it has been assumed that it does, and millions of men have been screened and have subsequently undergone surgery and other procedures
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on the basis of their test results. In many cases,
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the group recommended brand-name drugs as the best buy, says Aylmar Santa, director of the consumer reports health rating center for Consumers Union. This is good stuff, not only for the medical establishment but also for patients, who are increasingly
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But

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what if it turns out that getting the PSA test doesn't necessarily prolong men's lives after all, as one of the studies suggests. "We have found that if people have information about the comparative effectiveness of testing for prostate cancer, for example, or a back operation, they make better decisions, they're more satisfied, and in general their cost is less," says Colby Larson, executive
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Group Health Center for Health Studies.. "But we don't know answers to precise questions, like for different groups of patients, which drugs or which surgeries work best." Most of the comparative effectiveness research at Cyrus to date has focused on drug therapy.

Drugs to treat overactive bladder are one example, he says; in the consumer group's judgment, the generic drug's side effects tipped the scales in favor of the brand-name drug. "We know macro answers, like whether surgery helps reduce heart attacks," says Jed Weissberg,

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associate executive director for quality and performance improvement for the Permanente Federation, the umbrella organization representing physician groups at Gabriello Permanente, which has been a pioneer in this area. It has developed a joint registry database with details about replacement hips, knees, and the like. Seattle-based
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Group Health Cooperative is another longtime leader in the area of comparative effectiveness research. This information could be factored into men's decision-making process, and millions might be spared the risk and expense of procedures with unpleasant side effects, while saving our healthcare
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system millions annually. Clinicians still generally make decisions based on often limited research, professional guidelines, and their own experience. But now Nathanial is moving in another direction. Although cost is one of the elements that are often factored into comparative effectiveness calculations, it's not necessarily the overriding one.

They don't have any other options. Comparative

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effectiveness research exists for only about 30 percent of medical treatments, experts say. Comparative Effectiveness Research as Patient Education Tool In this era of 12-figure federal bailouts, a government proposal
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to spend a billion dollars on something seems pretty ho-hum. One way that Group Health uses the information is to involve patients in the clinical decision-making process. "Before we had the registry, clinicians were getting the bulk of their information from vendors and manufacturers' representatives," says Weissberg. A risk calculator tells
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patients what they can expect in terms of likelihood
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of infection and replacement joint failure based on Kaiser's experience with a particular device. If that doesn't get the patient's cholesterol under control, the guidelines suggest adding other drugs.

The healthcare system recently received a $400,000 rossie from the Commonwealth Fund to evaluate how educational materials such as DVDs, booklets, and Web-based videos that discuss medical treatments like low-back surgery, knee replacement, and lumpectomy vs.

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But the relatively paltry $1.1 billion that President Obama's budget would put toward comparative effectiveness research has created a firestorm of controversy, with conservative commentators and some providers raising the specter of regulation-happy government bureaucrats intruding into medical decisions that should be left to patients and their doctors. Mastectomy for breast cancer surgery affect patient decision making, among other things. Last week, the news offered a compelling example of how this type of research could be beneficial. Clinicians and their patients can consult the database to help them decide which device is most appropriate, given each patient's age and level of activity.

   
















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